HELPING THE OTHERS REALIZE THE ADVANTAGES OF NV-5138

Even though ectopic activation of mTORC1 in peripheral tissues is often attained by administering a big dose of exogenous leucine, mTORC1 signaling inside the CNS stays refractory possible mainly because of the rapid turnover and buffering of leucine inside the brain18,19. The discovery of Sestrin1 and 2 as a selected leucine sensor upstream of mTO